Vaccination for COVID patients ?

SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors

https://pubmed.ncbi.nlm.nih.gov/34051441/

https://doi.org/10.1016/j.ebiom.2021.103401

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00194-8/fulltext

In lemonde.fr (*1) :

"Des études ont montré que les personnes infectées avaient produit des

anticorps capables de contrer le SARS-CoV-2, mais la durée de

l’immunité conférée demeure incertaine. La Haute Autorité de santé

(HAS), estime dans des recommandations (*2) publiées en février que

les personnes ayant déjà contracté le Covid-19 peuvent se considérer

comme protégées pendant au moins trois mois. Elle recommande

d’attendre de préférence six mois après l’infection, et de

n’administrer qu’une dose de vaccin."

(*1) https://www.lemonde.fr/les-decodeurs/article/2021/01/21/a-quel-point-les-vaccins-sont-ils-efficaces-quels-effets-secondaires-ont-ils-ete-observes-nos-reponses-a-vos-questions_6067093_4355770.html

(*2) https://www.has-sante.fr/jcms/p_3237456/fr/une-seule-dose-de-vaccin-pour-les-personnes-ayant-deja-ete-infectees-par-le-sars-cov-2

Vaccines / France : 

https://www.gouvernement.fr/sites/default/files/cimages/infog_publics_x_vaccins_v10-05.png

https://www.gouvernement.fr/info-coronavirus/vaccins

Doctolib : #DéfiVacination

https://twitter.com/doctolib/status/1392515701169168390

https://info.doctolib.fr/blog/plus-de-2-millions-de-rendez-vous-pris-suivez-levolution-de-la-campagne-vaccinale-au-plus-pres-de-chez-vous/

https://info.doctolib.fr/blog/category/defi-vaccination/

https://about.doctolib.fr/vaccination/statistiques.html

Comment se faire vacciner ?

La vaccination ne s’effectue que sur rendez-vous :

+ sur sante.fr ;

+ par téléphone : 0 800 009 110 (7 jours/7 de 06h00 – 22h00) ;

+ auprès de votre médecin traitant ;

https://www.gouvernement.fr/info-coronavirus/vaccins

Chronodoses : 

https://vitemadose.covidtracker.fr/centres-vaccination-covid-dpt94-val_de_marne/commune94043-94270-le_kremlin_bicetre/recherche-chronodoses/en-triant-par-distance

ViteMaDose : 

https://vitemadose.covidtracker.fr/

https://covidtracker.fr/

https://twitter.com/covidtracker_fr

https://twitter.com/guillaumerozier

https://www.linkedin.com/in/guillaume-rozier/

https://www.lci.fr/sante/coronavirus-covid-19-vaccination-l-executif-n-exclut-pas-une-ouverture-aux-plus-de-18-ans-avant-le-15-juin-2186192.html

https://solidarites-sante.gouv.fr/IMG/pdf/fiche_effets_indesirables_comirnaty_pfizer_biontech.pdf

The mRNA (Pfizer BioNTech and Moderna) Covid vaccines should remain highly effective against two coronavirus variants first identified in India

https://www.france24.com/en/live-news/20210517-pfizer-moderna-vaccines-effective-against-indian-variants-study

https://www.nytimes.com/2021/04/22/health/covid-ny-variant-vaccine.html

https://nyulangone.org/news/new-york-times-studies-find-covid-vaccines-are-effective-against-new-york-variant

NYU / Nathaniel "Ned" Landau : https://med.nyu.edu/faculty/nathaniel-r-landau

https://www.youtube.com/watch?v=-kMGLdblYUY

The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India

Provide Partial Resistance to Vaccine-elicited and Therapeutic Monoclonal

Antibodies

https://www.biorxiv.org/content/10.1101/2021.05.14.444076v1

https://www.biorxiv.org/content/10.1101/2021.05.14.444076v1.full.pdf

Jean-Paul Hamon, médecin généraliste à Clamart, opère un rappel à l’ordre qu’il juge « nécessaire » : « Sincèrement, l’AstraZeneca est un bon vaccin. Il y a un cas de thrombose pour 120 000 personnes (NDLR, pour 421 909 personnes, selon les analyses du Parisien), quand on diagnostique environ 4 cas de thrombose pour 10 000 femmes qui prennent la pilule », insiste-t-il.

https://www.leparisien.fr/societe/sante/astrazeneca-et-thrombose-5-minutes-pour-comprendre-les-soupcons-autour-de-la-mort-dun-etudiant-a-nantes-02-05-2021-7WRQ7KFAEFD25HWJTEAD42SOFE.php

AstraZeneca vaccine: Denmark stops rollout completely

https://www.bbc.com/news/world-europe-56744474

https://www.bbc.com/news/av-embeds/56744474/vpid/p093wm4k

https://www.nytimes.com/2021/02/07/world/africa/covid-vaccine-astrazeneca-south-africa.html

Genomic Epidemiology : 

https://nextstrain.org/ncov/global

https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2

"Kent" Variant / South East of England : 

https://en.wikipedia.org/wiki/Nextstrain

https://covariants.org/variants/S.501Y.V1

https://en.wikipedia.org/wiki/GISAID

https://www.nature.com/articles/d41586-021-01069-w

https://en.wikipedia.org/wiki/Lineage_(genetic)

https://cov-lineages.org/global_report_B.1.1.7.html 

"India" Variant : https://cov-lineages.org/lineages/lineage_B.1.617.1.html

https://www.npr.org/sections/goatsandsoda/2021/05/07/994710459/is-the-variant-from-india-the-most-contagious-coronavirus-mutant-on-the-planet?t=1620485215385

https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

Patents / US vs. Eu

https://twitter.com/AmbassadorTai/status/1390021205974003720

https://twitter.com/AmbassadorTai/status/1390021205974003720/photo/1

https://www.nytimes.com/2021/05/05/us/politics/biden-covid-vaccine-patents.html

https://www.reuters.com/business/healthcare-pharmaceuticals/biden-says-plans-back-wto-waiver-vaccines-2021-05-05/

https://www.nature.com/articles/d41586-021-01224-3

https://www.reuters.com/world/china/vaccine-ip-waiver-could-take-months-wto-negotiate-experts-2021-05-06/

https://www.reuters.com/world/europe/eu-split-vaccine-waiver-idea-unlikely-take-clear-stance-2021-05-07/

France / Lockdown / Relax Curfew : 

 https://www.insee.fr/fr/statistiques/4931039?sommaire=4487854

https://www.france24.com/en/tag/francelockdown/

https://www.france24.com/en/europe/20210429-covid-19-france-aims-to-relax-curfew-allow-outdoor-dining-and-reopen-cultural-venues-from-may-19

COVID-19 Variants : India & South Africa Variants

https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2

https://www.who.int/news-room/feature-stories/detail/the-effects-of-virus-variants-on-covid-19-vaccines

https://www.youtube.com/watch?v=qD8dAbov5JU

https://en.wikipedia.org/wiki/Phylogenetic_Assignment_of_Named_Global_Outbreak_Lineages

https://pangolin.cog-uk.io/

https://github.com/cov-lineages/pangolin

https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-emerging-variants.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fmore%2Fscience-and-research%2Fscientific-brief-emerging-variants.html

https://cov-lineages.org/index.html

https://cov-lineages.org/lineages.html

https://www.youtube.com/watch?v=xLvY210yQkE

https://www.youtube.com/watch?v=DYkIKU_PcBc

Indian Variant : 

https://en.wikipedia.org/wiki/Lineage_B.1.617

https://cov-lineages.org/lineages/lineage_B.1.617.html

https://outbreak.info/situation-reports?pango=B.1.617&loc=IND&loc=GBR&loc=USA&selected=IND

South Africa Variant : 

https://en.wikipedia.org/wiki/501.V2_variant

https://cov-lineages.org/lineages/lineage_B.1.351.html

https://outbreak.info/situation-reports?pango=B.1.351

https://cov-lineages.org/

https://outbreak.info/

https://github.com/outbreak-info/R-outbreak-info

https://api.outbreak.info/try/covid19

https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

UK Variant & Paris, France 3rd Lockdown :

https://en.wikipedia.org/wiki/Lineage_B.1.1.7

https://fr.wikipedia.org/wiki/VOC-202012/01

https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2

https://cov-lineages.org/lineages.html

+64% Mortality

Results : The mortality hazard ratio associated with infection with VOC-20201
2/1 compared with infection with previously circulating variants was 1.64 (95% confidence interval 1.32 to 2.04) in patients who tested positive for covid-19 in the community. In this comparatively low risk group, this represents an increase in deaths from 2.5 to 4.1 per 1000 detected cases.

Main outcome measure : Death within 28 days of the first positive SARS-CoV-2 test result.

Source : British Medical Journal https://www.bmj.com/content/372/bmj.n579

"KentCOVID" Kent variant

https://eminetra.co.uk/coronavirus-uk-kentcovid-variants-are-twice-as-deadly-as-older-versions/341988/

https://i.dailymail.co.uk/1s/2021/03/10/12/40294636-9346311-image-a-37_1615380263631.jpg

Other UK Variants : 

https://www.gov.uk/government/publications/covid-19-variants-genomically-confirmed-case-numbers/variants-distribution-of-cases-data#definition

https://www.healthline.com/health-news/heres-how-fast-the-u-k-covid-19-variant-can-spread-in-the-u-s

https://www.cdc.gov/mmwr/volumes/70/wr/mm7003e2.htm?s_cid=mm7003e2_w

3rd Lockdown in Paris, France : 

https://www.france24.com/en/france/20210318-france-to-announce-new-coronavirus-restrictions-for-the-paris-region

https://www.france24.com/en/tv-shows/in-the-press/20210319-f-one-month-french-papers-react-to-third-parisian-lockdown

https://www.francebleu.fr/infos/sante-sciences/covid-19-le-variant-anglais-retrouve-dans-environ-1-des-tests-positifs-en-france-d-apres-olivier-1610475915

Learn mRNA : 

https://www.modernatx.com/mrna-technology/science-and-fundamentals-mrna-technology

https://www.youtube.com/watch?v=Rn9sRkkqGT4

https://www.modernatx.com/moderna-blog/shedding-light-our-prophylactic-vaccines-moa

https://biontech.de/how-we-translate/mrna-therapeutics

https://en.wikibooks.org/wiki/An_Introduction_to_Molecular_Biology

https://en.wikibooks.org/wiki/An_Introduction_to_Molecular_Biology/Transcription_of_RNA_and_its_modification

https://en.wikibooks.org/wiki/An_Introduction_to_Molecular_Biology/Transcription_of_RNA_and_its_modification#mRNA_and_its_modification

https://en.wikibooks.org/wiki/An_Introduction_to_Molecular_Biology/Transcription_of_RNA_and_its_modification#Splicing_of_RNA

https://commons.wikimedia.org/wiki/Wikipedia_for_World_Heritage

It’s not too soon to start thinking about the next pandemic.

https://www.youtube.com/watch?v=OJtblo12UxI

https://www.gatesnotes.com/2021-Annual-Letter?WT.mc_id=20210127000001_AL2021_BG-LI_&WT.tsrc=BGLI

+ Mega Testing Diagnostic Platforms (20% of population / week)

+ Get Treatments out faster

+ Monoclonal Antibodies ? 

https://en.wikipedia.org/wiki/Monoclonal_antibody

+ Develop New Vaccines quickly (mRNA)

https://en.wikipedia.org/wiki/Messenger_RNA

+ Global Alert System

+ Infectious Disease Responders

mRNA Vaccines Patents : 

https://www.nature.com/articles/d41573-020-00119-8

https://www.citizen.org/article/biontech-and-pfizers-bnt162-vaccine-patent-landscape/

https://biontech.de/how-we-translate/mrna-therapeutics

BNT162b2 mRNA Vaccine from BioNTech, Pfizer & Fosun Pharma : 

https://www.wsj.com/articles/moderna-and-pfizer-are-reinventing-vaccines-starting-with-covid-11605638892

https://www.wsj.com/video/vaccine-economics-where-profit-and-public-health-collide/5357E450-D89B-4619-B889-CD31166E3D41.html

https://en.wikipedia.org/wiki/RNA_vaccine

https://en.wikipedia.org/wiki/Pfizer%E2%80%93BioNTech_COVID-19_vaccine

https://fr.wikipedia.org/wiki/Tozinam%C3%A9ran

The BioNTech-Pfizer partnership is worldwide except China, where BioNTech is partnering with Fosun Pharma to jointly develop BNT162.

https://www.genengnews.com/covid-19-candidates/biontech-pfizer-and-fosun-pharma-bnt162/

https://www.who.int/emergencies/diseases/novel-coronavirus-2019/covid-19-vaccines

https://extranet.who.int/pqweb/sites/default/files/documents/Status_COVID_VAX_01Feb2021.pdf

https://www.who.int/publications/i/item/background-document-on-mrna-vaccine-bnt162b2-(pfizer-biontech)-against-covid-19

https://apps.who.int/iris/rest/bitstreams/1327316/retrieve

https://apps.who.int/iris/handle/10665/338484

https://apps.who.int/iris/bitstream/handle/10665/338484/WHO-2019-nCoV-vaccines-SAGE_recommendation-BNT162b2-2021.1-eng.pdf?sequence=1&isAllowed=y

https://www.nature.com/articles/d41586-021-00316-4

https://doi.org/10.1038/d41586-021-00316-4

https://github.com/hrossman/Patterns-of-covid-19-pandemic-dynamics-following-deployment-of-a-broad-national-immunization-program/blob/main/2021-02-03%20%20-%20Patterns%20of%20covid-19%20pandemic%20dynamics%20following%20deployment%20of%20a%20broad%20national%20immunization%20program.pdf

4000+ COVID Variants

Source : UK Vaccine Deployment Minister Nadhim Zahawi

https://www.reuters.com/article/us-health-coronavirus-britain-idCAKBN2A40U0

https://learningenglish.voanews.com/a/britain-s-vaccine-chief-says-world-faces-4-000-covid-19-variants/5765566.html

https://www.leparisien.fr/societe/sante/le-covid-19-a-deja-genere-4000-variants-04-02-2021-8423097.php

https://edition.cnn.com/2021/01/28/health/variants-coronavirus-new-popping/index.html

Vaccines for Data: 

Israel's Pfizer Deal Drives Quick Rollout — And Privacy Worries

https://www.npr.org/2021/01/31/960819083/vaccines-for-data-israels-pfizer-deal-drives-quick-rollout-and-privacy-worries

https://govextra.gov.il/media/30806/11221-moh-pfizer-collaboration-agreement-redacted.pdf

Vaccines: contract between European Commission and AstraZeneca

https://ec.europa.eu/commission/presscorner/detail/en/ip_21_302

https://ec.europa.eu/commission/presscorner/api/files/attachment/867990/APA%20-%20AstraZeneca.pdf

https://www.lalibre.be/international/europe/un-logiciel-permet-de-lire-certains-passages-occultes-du-contrat-entre-la-commission-europeenne-et-astrazeneca-6014369f7b50a652f751acea

COVID-19 Variants : UK, South Africa, Japan

https://www.who.int/csr/don/31-december-2020-sars-cov2-variants/en/

https://www.who.int/csr/don/21-december-2020-sars-cov2-variant-united-kingdom/en/

https://www.who.int/csr/don/archive/year/2020/en/

https://www.gisaid.org/epiflu-applications/hcov-19-reference-sequence/

https://en.wikipedia.org/wiki/Variant_of_Concern_202012/01

https://www.bmj.com/content/371/bmj.m4857

https://asia.nikkei.com/Spotlight/Coronavirus/Japan-finds-new-COVID-virus-strain-distinct-from-UK-and-Africa-types

https://www.niid.go.jp/niid/en/

Mink in Denmark

https://www.who.int/csr/don/03-december-2020-mink-associated-sars-cov2-denmark/en/

https://www.reuters.com/article/us-health-coronavirus-china-mink-idUSKBN28D0PV

https://www.dw.com/en/mink-fur-boom-in-china-raises-virus-fears/av-55820479

https://www.youtube.com/watch?v=O5E_ykbTF5E

https://en.wikipedia.org/wiki/Mink_industry_in_Denmark#COVID-19

https://en.wikipedia.org/wiki/Mink_industry_in_Denmark

https://en.wikipedia.org/wiki/Fur_farming

Reverse Engineering of the code SARS-CoV-2 Vaccine from BioNTech / Pfizer 

(with a Computer Science CS Hacker-like view)

https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/

Sequence / Séquence 

GAGAAΨAAAC ΨAGΨAΨΨCΨΨ CΨGGΨCCCCA CAGACΨCAGA GAGAACCCGC   50

CACCAΨGΨΨC GΨGΨΨCCΨGG ΨGCΨGCΨGCC ΨCΨGGΨGΨCC AGCCAGΨGΨG  100

ΨGAACCΨGAC CACCAGAACA CAGCΨGCCΨC CAGCCΨACAC CAACAGCΨΨΨ  150

ACCAGAGGCG ΨGΨACΨACCC CGACAAGGΨG ΨΨCAGAΨCCA GCGΨGCΨGCA  200

CΨCΨACCCAG GACCΨGΨΨCC ΨGCCΨΨΨCΨΨ CAGCAACGΨG ACCΨGGΨΨCC  250

ACGCCAΨCCA CGΨGΨCCGGC ACCAAΨGGCA CCAAGAGAΨΨ CGACAACCCC  300

GΨGCΨGCCCΨ ΨCAACGACGG GGΨGΨACΨΨΨ GCCAGCACCG AGAAGΨCCAA  350

CAΨCAΨCAGA GGCΨGGAΨCΨ ΨCGGCACCAC ACΨGGACAGC AAGACCCAGA  400

GCCΨGCΨGAΨ CGΨGAACAAC GCCACCAACG ΨGGΨCAΨCAA AGΨGΨGCGAG  450

ΨΨCCAGΨΨCΨ GCAACGACCC CΨΨCCΨGGGC GΨCΨACΨACC ACAAGAACAA  500

CAAGAGCΨGG AΨGGAAAGCG AGΨΨCCGGGΨ GΨACAGCAGC GCCAACAACΨ  550

GCACCΨΨCGA GΨACGΨGΨCC CAGCCΨΨΨCC ΨGAΨGGACCΨ GGAAGGCAAG  600

CAGGGCAACΨ ΨCAAGAACCΨ GCGCGAGΨΨC GΨGΨΨΨAAGA ACAΨCGACGG  650

CΨACΨΨCAAG AΨCΨACAGCA AGCACACCCC ΨAΨCAACCΨC GΨGCGGGAΨC  700

ΨGCCΨCAGGG CΨΨCΨCΨGCΨ CΨGGAACCCC ΨGGΨGGAΨCΨ GCCCAΨCGGC  750

AΨCAACAΨCA CCCGGΨΨΨCA GACACΨGCΨG GCCCΨGCACA GAAGCΨACCΨ  800

GACACCΨGGC GAΨAGCAGCA GCGGAΨGGAC AGCΨGGΨGCC GCCGCΨΨACΨ  850

AΨGΨGGGCΨA CCΨGCAGCCΨ AGAACCΨΨCC ΨGCΨGAAGΨA CAACGAGAAC  900

GGCACCAΨCA CCGACGCCGΨ GGAΨΨGΨGCΨ CΨGGAΨCCΨC ΨGAGCGAGAC  950

AAAGΨGCACC CΨGAAGΨCCΨ ΨCACCGΨGGA AAAGGGCAΨC ΨACCAGACCA 1000

...

ACCΨCGGGΨC CCAGGΨAΨGC ΨCCCACCΨCC ACCΨGCCCCA CΨCACCACCΨ 4000

CΨGCΨAGΨΨC CAGACACCΨC CCAAGCACGC AGCAAΨGCAG CΨCAAAACGC 4050

ΨΨAGCCΨAGC CACACCCCCA CGGGAAACAG CAGΨGAΨΨAA CCΨΨΨAGCAA 4100

ΨAAACGAAAG ΨΨΨAACΨAAG CΨAΨACΨAAC CCCAGGGΨΨG GΨCAAΨΨΨCG 4150

ΨGCCAGCCAC ACCCΨGGAGC ΨAGCAAAAAA AAAAAAAAAA AAAAAAAAAA 4200

AAAAGCAΨAΨ GACΨAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 4250

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAA                  4284

Ψ = 1-methyl-3'-pseudouridylyl

https://mednet-communities.net/inn/db/media/docs/11889.doc

https://twitter.com/chabrerie

Pandemic vs. Vaccine race will take time

Pandemic : should pass 100M cases & 2M deaths in 2021.

Taiwan’s Model for Combating COVID-19: A Small Island with Big Data

Population : 23 million 

600 confirmed cases 

7 deaths

Advantage :  previous experience with the Severe Acute Respiratory Syndrome (SARS).

“Taiwan Model” :
Lessons learned from the SARS Epidemic
Early Actions: Border Control
Central Epidemic Command Center
Contact Tracing Utilizing Smart Technology (Big Data including Mobile Phone Data)
Quarantine Enforcement
Lessons Learned !

https://www.mei.edu/publications/taiwans-model-combating-covid-19-small-island-big-data

 More than 1M deaths WorldWide ! : 

https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

Third Wave starting.