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20200423

FRANCE / Open Source ICU Ventilator
MakAir
https://makair.life/
https://github.com/makers-for-life/makair/
Medical contacts : 
http://www.itun.nantes.inserm.fr/Team-5/Pierre-Antoine-Gourraud
+ ST / NUCLEO_F411RE
On the MotherBoard
stm32duino
https://github.com/makers-for-life/makair/tree/master/src/software/firmware
https://github.com/makers-for-life/makair
https://github.com/makers-for-life/makair/blob/master/src/electronics/motherboard/schematics/V2/Electrical%20Schematics.pdf
+ PID
https://fr.wikipedia.org/wiki/R%C3%A9gulateur_PID
https://en.wikipedia.org/wiki/PID_controller
SEB
https://www.bfmtv.com/economie/covid-19-seb-va-produire-un-respirateur-artificiel-a-bas-couts-1898929.html
CEA
http://www.cea.fr/presse/Pages/actualites-communiques/sante-sciences-du-vivant/covid19-dispositifs-assistance-respiratoire-urgence-.aspx
Porteurs principaux du projet : Makers For Life, CHU de Nantes, Université de Nantes et CEA
Collectivités, Administrations et Associations : Région Auvergne Rhône-Alpes, Région Pays de Loire, Nantes Métropole, DGE, AID, SFMC
Partenaires industriels : Tronico, Parrot, STMicroelectronics, Diabeloop, Maatel, Groupe Renault, Michelin, Legrand, Groupe SEB, Elpack Pharel
Partenaires académiques et hospitaliers : CHRU Brest, CHU de Grenoble L’école du design, IUT Nantes, Centrale Nantes, Clinatec, Polytech Nantes, Laboratoire LS2N
Partenaires plasturgies : Innovation Plasturgie Composites, Georges Pernoud, Zedes, Seco Industries, Fédération de la Plasturgie et des Composites, DPH International, Moules Soufflage Injection
Partenaires entreprises : Clever Cloud, Crisp, RTSys, Jabby Technologies, SenX, QBMaker, MD101 Consulting, Sleepinnov, Le Palace, Dici Design Renault Sport, Cooprint,  Pierre Pezet, Iliad, Altran, Oxygen Ouest, Le Palace, ASI, Semtech, Farnell, Association Ping, Extia, Aptatio, Safran, HP, Algolinked, Asten Santé, WeData, LVL Medical, Vitalaire
Hommes et Femmes clés : Julien Tanguy, Morgane Soulard, Volodia Lepron, Pierre Papin, Clément Niclot, Cherine Kamel, Quentin Adam, Sandra Roze, Valérian Saliou, Edyta Bourgeais, Vincent Le Cunff, Marc Julien, Gabriel Moneyron, Gautier de Saint Martin Lacaze, David Sferruzza, Emmanuel Feller, Grégory Thibord, Erik Huneker, Cyril Michaud, Baptiste Jamin,Pierre-Antoine Gourraud, Stéphane Bernier, Arthur Dagard, Quentin Bouquin, Maud Plombas, Eliott Vincent.
https://unnews.univ-nantes.fr/le-makair-un-respirateur-artificiel-dedie-au-traitement-du-covid-19-pret-a-entrer-en-essais-cliniques--2635597.kjsp

20200420

FRANCE / Makers against COVID-19
At 3:40 : R&D Projects with
ICU Ventilator (MUR) &
Syringe Pump (Electrolab)
A good résumé by Mr. Bidouille of the different actions of the Makers in France (in French)
https://www.youtube.com/watch?v=lnM7UVT2i-o&t=220

20200416

Mobile
Bluetooth BLE
Apple and Google partner on COVID-19 contact tracing technology
https://www.blog.google/inside-google/company-announcements/apple-and-google-partner-covid-19-contact-tracing-technology/
https://www.apple.com/newsroom/2020/04/apple-and-google-partner-on-covid-19-contact-tracing-technology/
https://www.blog.google/documents/57/Overview_of_COVID-19_Contact_Tracing_Using_BLE.pdf
https://www.blog.google/documents/58/Contact_Tracing_-_Bluetooth_Specification_v1.1_RYGZbKW.pdf
https://www.blog.google/documents/56/Contact_Tracing_-_Cryptography_Specification.pdf
https://www.blog.google/documents/55/Android_Contact_Tracing_API.pdf
https://worldwide.espacenet.com/publicationDetails/biblio?II=6&ND=3&adjacent=true&locale=en_EP&FT=D&date=20101230&CC=US&NR=2010330903A1&KC=A1#
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2007063220
https://patentscope.wipo.int/search/en/detail.jsf?docId=US43505818
https://patentscope.wipo.int/search/en/detail.jsf?docId=FR187425572
US / Impact on Economy :
Up to one-third of US jobs may be vulnerable
and more than 80 percent are held by low-income workers.
Up to more than 50M jobs lost ?
https://www.mckinsey.com/industries/public-sector/our-insights/lives-and-livelihoods-assessing-the-near-term-impact-of-covid-19-on-us-workers
https://www.mckinsey.com/~/media/McKinsey/Industries/Public%20Sector/Our%20Insights/Lives%20and%20livelihoods%20Assessing%20the%20near%20term%20impact%20of%20COVID%2019%20on%20US%20workers/Lives-and-livelihoods-Assessing-the-near-term-impact-of-COVID-19-on-US-workers.ashx
https://www.cbia.com/news/economy/hospitality-healthcare-retail-covid-19-jobs-hit/
https://www.marketwatch.com/story/the-us-officially-lost-701000-jobs-in-march-but-in-reality-millions-vanished-2020-04-03?mod=article_inline
https://www.bls.gov/news.release/empsit.nr0.htm?mod=article_inline
https://www.marketwatch.com/story/jobless-claims-leap-record-66-million-at-end-of-march-as-coronavirus-triggers-mass-layoffs-2020-04-02?mod=article_inline

20200409

FRANCE / Virus Propagation
First Case Enigma
"Patient Zero" Enigma
https://fr.wikipedia.org/wiki/Patient_z%C3%A9ro
https://www.liberation.fr/france/2020/04/08/covid19-a-bord-du-charles-de-gaulle-l-inconnue-du-patient-zero_1784604
EPITA / COVID-19 :
https://newsroom.ionis-group.com/2020/04/09/les-etudiants-de-lepita-apportent-leur-aide-dans-la-lutte-contre-le-covid-19/

+ Open Source Syringe Pump Project : 
https://covid3d.org/projects/pousse-seringue 
https://covid3d.org/members
https://www.covid3d.org/contact
https://app.jogl.io/project/185
https://www.dagoma3d.com/dagoma-engagee-contre-le-covid-19
https://twitter.com/Dagoma3D/status/1247569928015818755
https://github.com/dagoma3d
https://covid-19.3ie.fr/
https://covid-19.3ie.fr/projet-pousse-seringue.html
https://www.epita.fr/recherche-innovation/equipes/
https://www.epita.fr/recherche-innovation/laboratoires-innovation-3ie/
https://www.nature.com/articles/s41598-019-48815-9
https://github.com/pachterlab/poseidon

+ Open Source ICU Ventilator Project :
https://en.wikipedia.org/wiki/Ventilator
https://www.mur-project.org/
https://github.com/LeClubSandwichStudio/MUR
Ranked #3 WW https://docs.google.com/spreadsheets/u/1/d/e/2PACX-1vTYAfldxoIiO46VAWH1NlhrwFBn9mguqS2bh1spnLEu4AVVN1cj1vaEm6vOp5Z6UnaAbUwd8dslCXdM/pubhtml#
https://www.groupeseb.com/fr/actualites/ensemble-face-au-covid-19

+ Protections :

https://healphi.org/
https://visieresolidaire.org/fr/
https://actu.fr/ile-de-france/coulommiers_77131/coronavirus-coulommiers-propose-soignants-fabriquer-visieres-partir-son-imprimante-3d_32626145.html

+ Folding@Home
https://foldingathome.org/

+ Education :
https://covid19.cristal.je/

https://newsroom.ionis-group.com/2019/09/03/lepita-ajoute-une-composante-sante-a-son-diplome-dingenieur-en-partenariat-avec-doctolib/

Other IONIS Group initiatives :
Sup'BioTech :
https://www.recherche.supbiotech.fr/covid19
https://www.recherche.supbiotech.fr/covid19en
ISG : 
https://planetesolidaire.optigest.fr/

3D Print / Masks
https://www.francetvinfo.fr/sante/maladie/coronavirus/l-hopital-juste-a-cote-demandait-250-masques-alors-j-ai-pris-la-commande-romeo-14-ans-fabrique-des-masques-chez-lui_3906057.html

20200404

Open Source / ICU Ventilator / Ranking
PB560
cpap respirator block diagram
https://www.st.com/en/applications/medical-and-healthcare/cpap-and-respirators.html
https://github.com/PubInv/covid19-vent-list
Recently Medtronic open-sourced one of their ventilators for the duration of the pandemic. However, it may not actually be usable for the most ill COVD-19 patients and does not meet the UK standard
https://twitter.com/RobertLeeRead/status/1246115416029749248
https://medium.com/@RobertLeeRead/medtronic-open-source-ventilator-does-not-meet-uks-rapidly-manufactured-ventilator-systems-81947c72a7ac
https://www.medtronic.com/us-en/e/open-files.html
Puritan Bennett(TM) 560 (PB560)
https://techcrunch.com/2020/03/30/medtronic-is-sharing-its-portable-ventilator-design-specifications-and-code-for-free-to-all/
"En France, Puritan Bennett avait pris le contrôle il y a trois ans d'une société spécialisée dans les appareils d'assistance respiratoire à domicile, Sefam."
https://www.lesechos.fr/1997/07/mallinckrodt-achete-nellcor-pour-12-milliards-de-francs-817785
"Créée en 1982 par Pierrick Haan à la sortie de son école d'ingénieurs"
https://www.lesechos.fr/1994/02/sefam-rachete-par-lamericain-puritan-bennett-876714
Sefam, Nancy, France 
http://www.sefam-medical.com/fr/notre-equipe/
https://www.linkedin.com/in/pierrick-haan-224ba8119/
TELECOM ParisTech 1980 (Sortie)
Board is based on ST10F278 (obsolete, replaced by STM32) from ST Microelectronics
ST10F276.h
Produced by Jabil
Source Code is in C.
Comments are in French.

FRANCE / APHP Projects :

Protection :
https://covid3d.org/projet_visiere

ICU Ventilator :
https://covid3d.org/projet_respirateur

Decathlon Mask :
https://covid3d.org/projet_masque_plongee

Syringe Pump :
https://covid3d.org/projet_pousse_seringue

P.S. : Warning Links have changed :
Example :
https://covid3d.org/projects/pousse-seringue
FRANCE / Companies
Corporates Act :

Accor
ADA
Air France
Air Liquide
Airbnb
Airbus
Alibaba
Auchan
AXA
Bacardi
Balenciaga
BNP Paribas
Bolloré Logistics
Bouygues
Bouygues Telecom
Brico Dépôt
Castorama
Chef français Eric Duquenne
CNES (i.e. Centre National d'Etudes Spatiales)
Cooper
Covea
Cristal Union
Dassault
Dassault Aviation
Decathlon
Dior
Faurecia
France Industrie
Free2Move
Fromagerie Maurice
Garnier
Generali France
Givenchy
Grey Goose
Gucci
Guerlain
Hermès
Île-de-France Mobilités
Iliad
Ipsen
JCDecaux
Kering
L'Oréal
La Poste
La Roche-Posay
Lips France
LVMH
Macif
MACSF
Malakoff Humanis
Nestlé
Opel France
Orange
PepsiCo France
Pernod-Ricard
PSA
RATP
Renault
Saint Laurent
Savonnerie Fer à Cheval
Schneider Electric
SNCF
Société Générale
Tereos
Total
Uber
Valeo

https://www.boursorama.com/bourse/actualites/dons-production-adaptee-respirateurs-l-engagement-des-entreprises-face-au-covid-19-3d3e5b5c2bbbd963ae2c71c2e5eab70d?symbol=1rPAI

FRANCE / ICU / R&D
AXA supports Fund 101 to develop Artificial Intelligence algorithms to predict the occurrence of complications in the treatment of the virus.
https://www.axa.com/en/newsroom/news/a-social-responsibility-bolstering-research-and-healthcare
https://www.argusdelassurance.com/les-assureurs/compagnies/coronavirus-axa-s-engage-aupres-des-chercheurs-et-des-professionnels-de-sante.162721
https://www.linkedin.com/company/101fund/about/
Data & AI Algorithms with Boston Consulting Group
https://www.parismatch.com/Actu/Sante/Coronavirus-le-cri-d-alarme-du-professeur-Chiche-1679947
Pr. Jean-Daniel CHICHE, Président Fonds 101, Réanimation Hôpital COCHIN, Paris
https://www.linkedin.com/in/jean-daniel-chiche-29901011/
https://www.youtube.com/watch?v=etomOnwERFg
https://one-o-one.eu/

20200403

WORLD : More than 1 Million cases confirmed Worldwide !


https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
3D Print / Protections
Cleaning & Distribution Procedure (in French) :
https://drive.google.com/file/d/1LU9QeKwA867tXclxlqmaXUsZaVeH-vZp/view?usp=sharing
https://drive.google.com/file/d/1957-FhykRcWufT_jwnJXhMCIk1yhUm94/view?usp=sharing

ApolloBVM Design :
FAQs :
What are the References for the Pressure Sensors ?
Why use 3 Arduino Boards ?
Why use 2 Motors ?

Source:
http://oedk.rice.edu/ApolloBVM-DIY#parts

BOM :
Motors (2x) - 2000 Series Dual Mode Servo (2000-0025-0002)
Arduino (3x) - Arduino Uno (A000066)
Pressure Sensors ... ?!?
20x4 LCD display

Software :
https://github.com/apollobvm/apollobvm
https://github.com/apollobvm/apollobvm/releases (NOT Yet ...)

Parameters :
  • Tidal Volume (TV): 300 - 650 mL (50 mL increments)
  • Respiratory Rate (RR): 5 - 30 BPM (1 BPM increments)
  • I:E Ratio: 1:2, 1:3, 1:4, 1:5

Parameter Range Default
Respiratory Rate (breaths/min) 5-30 12
VT (Tidal volume in cc, set at 6-8 cc/kg of ideal body weight) 300-650 500
I:E (Inspiratory time/Expiratory time per cycle) 1:2 to 1:4 1:3
PEEP (Positive end expiratory pressure in cmH20) 5-20 8

20200327

USA / MIT Open Source Ventilator Project :

MIT-based team works on rapid deployment of open-source, low-cost ventilator | MIT News
http://news.mit.edu/2020/ventilator-covid-deployment-open-source-low-cost-0326

The new device fits around an Ambu bag (blue), which hospitals already have on hand in abundance. Designed to be squeezed by hand, instead they are squeezed by mechanical paddles (center) driven by a small motor. This directs air through a tube which is placed in the patient's airway.



A project done a decade ago in the MIT class 2.75 (Medical Device Design)

https://e-vent.mit.edu/wp-content/uploads/2020/03/DMD-2010-MIT-E-Vent.pdf

https://e-vent.mit.edu/

ISRAEL / Ambu-Vent
https://presidentsreport.technion.ac.il/ventilators-for-life/
https://www.youtube.com/watch?v=H23wEDqV1LA


20200322

This video can save lives. Please share this link with people working at Hospitals.

COVID-19 How to Use One Ventilator to Save Multiple Lives
https://www.youtube.com/watch?v=uClq978oohY
Saving 4 Patients With Just 1 Ventilator
https://hackaday.com/2020/03/19/saving-4-patients-with-just-1-ventilator/


Open Source Projects :

https://hackaday.com/2020/03/12/ultimate-medical-hackathon-how-fast-can-we-design-and-deploy-an-open-source-ventilator/

https://www.agorize.com/fr/challenges/code-life-challenge





https://www.linkedin.com/posts/dgiluz_its-working-activity-6647896637630894081-FMSc/
https://dgiluz.wordpress.com/2020/03/23/its-working/


https://www.youtube.com/watch?v=w4Csqdxkrfw
+ 3D Printed "CHARLOTTE" Valve (vs. "CHARLOTTE" Valve + "DAVE" Valve + Reservoir vs. "CHARLOTTE" Valve + "DAVE" Valve + Reservoir + Venturi Valve)
PEEP https://en.wikipedia.org/wiki/Positive_end-expiratory_pressure
Venturi Valve https://www.moscorner.com/en/what-are-the-different-types-of-pneumatic-conveying/
+ Bottle of water (vs. PEEP vs. PEEP + Filter)
+ Tubes
https://www.3dprintingmedia.network/isinnova-shares-3d-printed-adapter-to-turn-snorkeling-mask-into-a-non-invasive-ventilator/

Coronavirus, l’azienda bresciana che ha trasformato una maschera da snorkeling in un respiratore
https://www.corriere.it/tecnologia/20_marzo_23/coronavirus-l-azienda-bresciana-che-ha-trasformato-maschera-snorkeling-un-respiratore-cdf7d0e2-6d14-11ea-ba71-0c6303b9bf2d.shtml?refresh_ce-cp

Decathlon
https://www.courrier-picard.fr/id77108/article/2020-03-23/le-masque-de-snorkelling-de-decathlon-comme-masque-de-protection-dans-les
https://france3-regions.francetvinfo.fr/hauts-de-france/pas-calais/coronavirus-seul-train-fret-chine-france-arret-decathlon-potentiellement-touche-1792455.html

https://www.3dprintingmedia.network/forums/topic/charlotte-valve-by-isinnova-for-non-invasive-ventilator/ 
https://www.linkedin.com/in/cristian-fracassi-b155b05b/
https://www.youtube.com/watch?v=e-sKJf74xuw
https://www.youtube.com/watch?v=w4Csqdxkrfw
https://www.youtube.com/watch?v=kpvkHsWz9VM
https://www.linkedin.com/in/filipkober/
https://www.plasticstoday.com/medical/updated-oem-threatens-sue-startup-saved-lives-3d-printing-medical-valves/123431165062652

https://hackaday.com/2020/03/16/3d-printed-parts-keep-respirators-operational-during-covid-19-epidemic/
https://www.3dprintingmedia.network/covid-19-3d-printed-valve-for-reanimation-device/

France :
https://www.mur-project.org/
https://github.com/LeClubSandwichStudio/MUR

USA :
https://hackaday.com/2020/03/18/can-a-cpap-fan-become-a-ventilator/
https://github.com/jcl5m1/ventilator
https://news.ycombinator.com/item?id=22599415
https://www.youtube.com/watch?v=n57u1NvXBgw
https://www.youtube.com/watch?v=oS6GA83nbds

https://hackaday.com/2020/03/22/coronavirus-and-foldinghome-more-on-how-your-computer-helps-medical-research/
https://hackaday.com/2020/03/18/join-team-hackaday-to-crunch-covid-19-through-foldinghome/

https://github.com/GliaX/faceshield

Imagen de un respiradero fabricado con impresoras 3D en la Zona Franca

https://translate.google.com/translate?hl=en&sl=auto&tl=en&u=https%3A%2F%2Fwww.lavanguardia.com%2Fvida%2F20200322%2F4830789695%2Frespirador-3d-coronavirus-consorci-de-la-zona-franca.html
https://www.lavanguardia.com/vida/20200322/4830789695/respirador-3d-coronavirus-consorci-de-la-zona-franca.html


Ventilator Modes

Parameters
https://www.youtube.com/watch?v=iP_jN1qAPtI

AC = ACV = Assist Control Ventilation = 16 breaths / minute

TV = Tidal Volume = 550 mL = 7 mL/kg
https://en.wikipedia.org/wiki/Tidal_volume

FiO2 = Fraction of inspired Oxygen = 50% (between 21% = air ... 50 % = Toxicity
https://en.wikipedia.org/wiki/Oxygen_toxicity)
https://en.wikipedia.org/wiki/Fraction_of_inspired_oxygen

PEP = PEEP = Positive End Expiratory Pressure = 5 cmH2O (between 0 ... 10)
https://en.wikipedia.org/wiki/Positive_end-expiratory_pressure
https://www.youtube.com/watch?v=iP_jN1qAPtI

https://sofia.medicalistes.fr/spip/IMG/pdf/Comment_administrer_l_oxygene_en_ventilation_spontanee_Pr_Levraut_.pdf

Information on COVID-19 for Hospitals :
https://openwho.org/channels/covid-19
Informations on Pandemic :
Pr Arnaud Fontanet, Institut Pasteur 
https://www.youtube.com/watch?v=c8hW1CVosno


COVID-19 : What South Korea has done ?
Testing times: Why South Korea's COVID-19 strategy is working | South Korea | Al Jazeera
https://www.aljazeera.com/programmes/upfront/2020/03/testing-times-south-korea-covid-19-strategy-working-200320051718670.html

Information on COVID19 :
https://www.who.int/emergencies/diseases/novel-coronavirus-2019
https://www.pasteur.fr/fr/centre-medical/fiches-maladies/coronavirus-wuhan
https://www.cdc.gov/coronavirus/2019-ncov/about/index.html
https://www.sf2h.net/wp-content/uploads/2020/01/2019-nCoV_fichesoignants22janv_vf.pdf
https://www.ecdc.europa.eu/en/novel-coronavirus-chinaTRAITE 
http://www.anios.com/covid19/FR/HC-HN-ECL-AN-5002-1-EU-0120-HC-INFO-NEWS-SHEET-DUAL-CORONAVIRUS-SARS-CoV-2-V2-FR.pdf

The secret of South-Korea = Mobile GeoLocalisation ?

Balance between Data Privacy vs. Public Health ?

Mobile Phones Geo-Localization
https://www.youtube.com/watch?v=KdSRMrYdxVY
https://www.linkedin.com/in/jerome-kim-70119424/
https://www.ivi.int/jerome-kim-for-korea-factual-hong-kongs-handling-of-covid-19-outbreak-prospects-of-vaccine-development/

How to "clean" / "kill" COVID-19 ?

+ Bleach
"Eau de Javel" https://translate.google.fr/?hl=fr#view=home&op=translate&sl=auto&tl=fr&text=bleach
https://fr.wikipedia.org/wiki/Eau_de_Javel
https://en.wikipedia.org/wiki/Sodium_hypochlorite
https://en.wikipedia.org/wiki/Claude_Louis_Berthollet

+ Alcohol
https://www.rutgers.edu/news/best-ways-kill-coronavirus-your-home

+ Profesional
http://www.anios.com/en/who-are-we/history.html


Where to find HEPA filters ?

HEPA (i.e. High-Efficiency Particulate Air)
https://en.wikipedia.org/wiki/HEPA

https://en.wikipedia.org/wiki/HEPA#Applications


NEEDED : Masks & Ventilators

https://mobilitygoesadditive.org/market-de/coronavirus-your-3d-printing-expertise-is-needed-urgent-request-from-the-european-commission/

https://translate.google.com/translate?hl=en&sl=auto&tl=en&u=https%3A%2F%2Fwww.railgrup.net%2Fcms%2F1%2F1349%2Fllamado-al-ecosistema-railgrup-requerimiento-urgente-de-la-comision-europea-impresion-3d

https://www.railgrup.net/uploads/adjuntos/1584609100-200317_ecreguest_information_and_contact_v3-1pdf

DIY Mask

https://translate.google.com/translate?hl=en&sl=auto&tl=en&u=http%3A%2F%2Fwww.aitasit.org%2Fwp49%2F2020%2F03%2F15%2Fprogetti-open-source-autoproduzione-mascherine%2F
http://www.aitasit.org/wp49/2020/03/15/progetti-open-source-autoproduzione-mascherine/

https://www.opensourcemask.com/en/

https://www.opensourcemask.com/en/download-file.html

https://www.opensourcemask.com/en/download-file/8-aitasit-associazione-italiana-amministratori-di-sistema-e-telemedicina-italy.html

https://www.3dline.it/it/home/53-file-3d-mascherina-di-protezione-facciale.html

https://www.opensourcemask.com/en/download-file/6-download.html

https://www.opensourcemask.com/en/download-file/7-iczfirz-honk-kong.html
https://www.thingiverse.com/iczfirz/about

https://www.3dnatives.com/en/mask-against-covid-19-180320205/
https://www.linkedin.com/in/danielmartinezpereira

https://hackaday.com/2020/03/18/homemade-masks-in-a-time-of-shortage/

#COVID19 South Korea, an example to follow ?
#COVID19 COVID-19 Real Time Data on Global Pandemic with Map